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Article Type

Original Study

Subject Area

Rhinology, Endoscopic sinus surgery

Abstract

Aim An increasing number of coronavirus disease 2019 (COVID-19) cases have started to experience unusual symptoms to the virus such as olfactory and gustatory dysfunctions. The study aimed to compare the effects of early corticosteroids (CS) administration versus no administration in the time-to-recovery from olfactory dysfunction in COVID-19. Patients and methods This comparative, nonrandomized study has been conducted at Benha University Hospital and another Primary Health Center in Cairo, Egypt, from January 2021 to June 2021. A total of 83 patients who have met the inclusion criteria were assigned into two groups: early-CS group (41 cases) and no-CS group (42 cases). Results Both groups were comparable regarding age, BMI, and sex. Females constituted 65.9 and 59.5% of cases in the early-CS group and the no-CS group, respectively. At presentation, regarding the severity of anosmia, both groups were comparable (P=0.302). Complete anosmia was reported in 80.5 and 78.6% of the early-CS group and the no-CS group, respectively. The mean duration for anosmia onset was 3.71 and 4.11.8 days in the early-CS group and the no-CS group, respectively (P=0.204). Time-to-recovery from anosmia was significantly less in the early-CS group, with a median (interquartile range) of 7 (9) days than in the no-CS group, with 14 (10) days (P

Keywords

anosmia, corticosteroids, coronavirus disease 2019, olfactory dysfunction

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