Hypovitaminosis D and its relationship to nasal polyposis

Sameh M Zamzam, Lecturer of ENT, faculty of medicine, Cairo University, Cairo, Egypt.Follow
Hesham Mansour, Professor of ENT, faculty of medicine, Cairo University, Cairo, Egypt
Gaurav Subedi, Visitor resident of ENT, faculty of medicine, Cairo University, Cairo, Egypt.
Osama Metwaly, Lecturer of ENT, faculty of medicine, Cairo University, Cairo, Egypt.

Article Type

Original Study

Subject Area

Rhinology, Nose and paranasal sinuses, Allergy, Endoscopic sinus surgery, Nasal imaging

Abstract

Background: Chronic rhinosinusitis with polyposis (CRSwNP) is histo-pathologically characterized by dense infiltration of eosinophils along with cascade of inflammatory cytokines. This study aimed to discover the link between serum vitamin D levels and sinonasal polyposis. Material and methods: this study is a cross-sectional study that carried out at otolaryngology department, Cairo university, Egypt. It included 72 participants divided into two groups, 36 cases of CRSwNP and 36 healthy volunteers. Serum Vitamin D3 level was estimated by High performance liquid chromatography technique (HPLC) and disease severity in CT was evaluated by Lund Mackay Scoring. Results: a significant statistical difference between noted between patients and healthy individuals regarding serum 25-hydroxyl Vitamin D3. Also, the lower the serum Vitamin D3 (ng/ml) the higher the Lund-Mackay Score. Conclusion: this study can conclude that levels of 25-hydoxyl Vitamin D3 are low in sinonasal polyposis individuals, compared to that in healthy volunteers and lower levels of Vitamin D are associated with more severe form of disease in CT.

Keywords

25- Hydroxyl Vitamin D3, nasal polyposis, Lund-Mackay Score, HPLC.

Recommended Citation

Zamzam S, Mansour H, Subedi G, et al. Hypovitaminosis D and its relationship to nasal polyposis. Pan Arab J. Rhinol. 2022; 12 : -.
Available at: https://pajr.researchcommons.org/journal/vol12/iss2/3 DOI: https://doi.org/10.58595/2090-7559.1206