Approaches for Endotypes Classifications of Chronic Rhinosinusitis and Its Impact on Management and Prognosis

Mohamed O. Tomoum, Assistant Professor, Otolaryngology department, Faculty of Medicine, Tanta, Egypt
Elbasty Hazem, Assistant Lecturer, Otolaryngology department, Faculty of Medicine, Tanta, Egypt.Follow

Article Type

Review

Subject Area

Nasal polyps

Abstract

According to previous categorizations of chronic rhinosinusitis (CRS), it ̓s divided into CRS with and without polyps, so this may not provide accurate evaluation for prognosis and management. An endotype in CRS refers to pathophysiologic mechanisms identified by certain biomarkers. Utilizing endotypes to categorize CRS variants represents an emerging understanding of the various pathophysiological pathways that cause clinical variability of CRS symptoms. This review highlights common endotype based criteria for the identification of various CRS subtypes and further explores the progress of treatment and prognosis with each classification approach. Utilizing the inflammatory biomarkers to endotype different CRS variants highlights the potential opportunities for development of biomarker-directed biologic therapies in CRS patients. Type 2 cytokine, eosinophils, Ig-E, and CysLT provide the four popular but overlapping methods to classify endotypes of CRS phenotypes. This review highlights common endotype-based criteria for the identification of various CRS subtypes and further explores the progress of treatment and prognosis with each classification approach.

Keywords

Biologics; Sinusitis; Interleukins; Biomarkers; Nasal Polyps

Recommended Citation

Tomoum M, Hazem E. Approaches for Endotypes Classifications of Chronic Rhinosinusitis and Its Impact on Management and Prognosis. Pan Arab J. Rhinol. 2024; 14 : -.
Available at: https://pajr.researchcommons.org/journal/vol14/iss2/2 DOI: https://doi.org/10.58595/2090-7559.1235