•  
  •  
 

Article Type

Original Study

Subject Area

Rhinitis and its complication

Abstract

Background: Atrophic rhinitis (AR) is a chronic nasal condition characterized by mucosal and bony atrophy, crusting, and functional impairment. Traditional treatments provide limited symptomatic relief, and novel regenerative approaches like platelet-rich plasma (PRP) have shown promise in mucosal regeneration. Objective: To evaluate the safety and efficacy of PRP injections in treating AR. Patients and Methods: A prospective study was conducted on 20 patients with AR, recruited from the Otorhinolaryngology Department, Cairo University. PRP was prepared from autologous blood and injected into the nasal mucosa at two-week intervals for three sessions. Clinical outcomes were assessed before and six months after treatment using the Sino-Nasal Outcome Test-25 (SNOT-25), nasal endoscopy, and mucociliary clearance time (MCT) by Saccharin Transit Time (STT). Statistical analysis was performed to evaluate the differences. Results: The mean age of participants was 36.80 ± 10.25 years, with 80% female. Significant improvement in SNOT-25 scores was observed, decreasing from 39.00 ± 5.98 to 13.00 ± 2.25 (P < 0.001). MCT improved from 1930.00 ± 293.02 seconds to 946.00 ± 107.72 seconds (P < 0.001). Nasal crusting resolved in 80% of patients, and mucosal appearance normalized in all cases (P < 0.001). There were no serious adverse effects, with only one patient experiencing mild, self-limited bleeding. Conclusions: PRP injections are a safe, effective, and minimally invasive treatment for AR, significantly improving symptoms, mucosal health, and mucociliary function. PRP holds promise as a novel therapeutic option for AR, warranting further investigation in larger trials.

Keywords

Atrophic Rhinitis; Platelet-Rich Plasma; Mucosal Regeneration; Sino-Nasal Outcome Test; Saccharin Transit Time

Download

Share

COinS