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Article Type

Article

Abstract

Introduction: Despite maximal medical and surgical therapies, subsets of patients continue to have persistent inflammation of paranasal sinuses, treatment of this group of patients, often referred to as recalcitrant chronic sinusitis, is quite challenging and is a subject of considerable debate in the medical literature.

Patients and Methods: Sinus cultures were obtained in 48 patients with recalcitrant sinusitis after ESS. Between January 2012 and January 2014, Antibiotics were stopped 7 days before cultures.

Results: Pseudomonas aeruginosa was isolated in 5(10.4%) patients, Staphylococcus aureus was isolated in 12(25%) patients and Aspergillus was isolated in 3(6.2%) patients. 28 (58.3%) patients showed no bacterial or fungal growth on culture.

Conclusion: Intracellular bacteria should be taken into consideration when designing novel treatment strategies to lessen the chance of reinfection.

More research is needed to know contributing factors in chronicity and resistance.

Keywords: Recalcitrant sinusitis, Biofilms, middle meatus culture, Local treatment.

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