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Article Type

Article

Abstract

Aims: Giant cell reparative granuloma is a non-neoplastic lesion rarely occurs and histologically is difficult to differentiate from giant tumor. We add our case to the few reported cases in the literature.

Methods: To report a case of a giant cell reparative granuloma of the ethmoidal region and to review the literature of all reported cases.

Results: Our case presented with only proptosis and lacrimation with recurrent infection but no history of trauma. Imaging study narrowed the differential diagnosis. Biopsy was diagnostic. Endoscopic complete resection of the Mass was performed with final histology of Giant cell reparative granuloma.

Histologically, giant cell reparative granuloma can be difficult to differentiate from giant cell tumor. Prior to Jaffe report on 1953 any bone lesion containing giant cells was thought to be a giant cell tumor or variant thereof. It represents a local hyperplastic reparative process after injury or secondary granulomatous lesion developing in the setting of infection or inflammation complicated by hemorrhage

Conclusions: Giant cell reparative granuloma (GCRG) is a rare condition affecting the mandible and maxilla. There are few of documented GCRG involving the facial bones or paranasal sinuses. Giant cell reparative granuloma should be considered when an expansile lesion is seen within the paranasal sinuses, bony orbit, or calvaria and MR shows isointensity with gray matter typical of a fibrous lesion, especially in a patient in the first two decades of life. Histopathological diagnosis is mandatory, surgical excision is the treatment of choice while radiotherapy is used in inoperable and recurrent cases.

Keyword: Giant Cell Reparative Granuloma, Ethmoid Sinus, Granuloma, Fibroosseous lesion

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