Article Type
Article
Abstract
Background: Intranasal corticosteroids are known to improve the symptoms of rhinosinusitis. However, in acute rhinosinusitis, the efficacy of intranasal corticosteroid used with oral antibiotics still needs further evidence.
Aim of Work: The aim of this study was to clinically compare the efficacy of topical corticosteroid and oral antibiotic combination therapy versus the use of oral antibiotic alone when treating acute rhinosinusitis regarding main symptoms (nasal obstruction, purulent nasal discharge, anosmia and facial pain), and also evaluating congestion and edema of middle meatus by using nasal endoscopy.
Materials and Methods: One hundred patients diagnosed with acute rhinosinusitis were divided into two groups. Group A received a combination of oral antibiotic (amoxicillin clavulanic acid) 50mg/kg/day for 10 days and local steroid spray (mometasone furoate) 2 sprays (50 mcg of mometasone furoate in each spray) in each nostril once daily for 10 days, while group B, the control
group, received the oral antibiotic alone. Follow-up was after 10 days with Sino-Nasal Outcome test questionnaire and nasal endoscopy. A comparison between both groups regarding major nasal symptoms and endoscopic findings was done.
Results: Group A showed superior results than group B, which received antibiotics alone, regarding the obstructive symptoms. There were statistical significant differences between both groups regarding nasal obstruction, hyposmia, facial pain, nasal congestion and edema at the middle meatus with p values 0.012,
0.013, < 0.001, and 0.006 respectively. There was no significant difference between the two groups as regards the purulent nasal discharge.
Conclusion: Intranasal corticosteroid spray in ABR is very useful when used beside oral antibiotics despite the minimal side effects reported. This showed a great effect in relieving obstructive symptoms and signs including nasal obstruction, hyposmia, facial pain, nasal congestion and edema at the middle turbinate.
Keywords: Acute rhinosinusitis, amoxicillin clavulanic acid, intranasal corticosteroid, mometasone furoate.
Recommended Citation
Zeid NG, Azooz KO, Hussein NM,
et al.
Efficacy of topical corticosteroids and oral antibiotic combination therapy vs Oral antibiotic alone in acute rhinosinusitis.
Pan Arab J. Rhinol.
2018;
8 : -.
Available at:
https://pajr.researchcommons.org/journal/vol8/iss1/2
