Article Type
Article
Abstract
Background: Bleeding is a major obstacle that faces the nasal endoscopiest. The aim of this study was to evaluate the efficacy and safety of large dose tranexamic acid (TA) in ensoscopic sinus surgery (ESS) for chronic sinusitis with sinonasal polyposis.
Patients and Methods: In a double-blinded, prospective, controlled study, 60 patients aged 20-50 years were randomly divided into two equal groups. The intervention group received (40 mg/kg) TA at induction of anesthesia followed by continuous infusion at a rate of 1mg/kg/hr. for the whole duration of surgery. The control group received an equivalent amount of saline as a placebo. The amount of blood loss, operative time, surgical field quality and complications were reported.
Results: TA group showed a significant reduction in intraoperative blood loss, improvement of quality of surgical field and less operative time.
Conclusion: Large dose of TA is safe and effective. It has a positive impact on reduction of blood loss, operative time and on surgical field quality without increased risk of complications.
Keywords: Tranexamic acid, Endoscopic sinus surgery, bleeding, chronic rhinosinusitis with sinonasal polyposis.
Recommended Citation
Fawaz M, Sabry R, Abd-Elmonaem S,
et al.
Outcomes of large dose Tranexamic acid in endoscopic sinus surgery for chronic sinusitis with sinonasal polyposis.
Pan Arab J. Rhinol.
2018;
8 : -.
Available at:
https://pajr.researchcommons.org/journal/vol8/iss2/7
